is a co-processed excipient produced by spray-drying a suspension of Microcrystalline Cellulose (MCC) and Colloidal Silicon Dioxide. It is widely used in the pharmaceutical field.

• Good liquidity and compressibility

  Colloidal silicon dioxide acts as a glidant for MCC. When uniformly distributed on the surface of MCC, it imparts superior flow properties. The excellent flowability and compressibility of SMCC enable it to perform outstandingly in various formulation processes, reducing production issues and costs.

• Low hygroscopicity

  The colloidal silicon dioxide on the particle surface interacts with water to form silanol groups. These groups can gradually adsorb additional moisture, preventing excess water from penetrating into the microcrystalline cellulose. This mechanism effectively isolates water from the active pharmaceutical ingredient.

• Extremely large surface area and high loading capacity

  Through a specialized processing technique, fine colloidal silicon dioxide particles are uniformly distributed partly on the surface and partly within the internal structure of MCC, resulting in an increased specific surface area.

• Multifunctionality

  SMCC can simultaneously function as a filler, binder, disintegrant, and stabilizer, reducing the number of excipients required in formulations and simplifying the formulation process. This multifunctionality makes SMCC highly versatile in pharmaceutical development, enabling it to meet the needs of various drug formulations.

1. Direct powder compression tabletting

   SMCC offers excellent flowability and compressibility, making it highly suitable for direct compression processes. It enhances tablet hardness and smoothness while reducing friability, thereby providing strong assurance for the appearance and quality of tablets.

2. Wet granulation

   In wet granulation processes, SMCC can serve as both a binder and a disintegrant, enhancing granule strength and disintegration performance.

3. Special dosage tablets

   SMCC improves blending uniformity and content homogeneity of formulations, effectively addressing process challenges such as the large volume of high-dose tablets and the uneven distribution of active ingredients in low-dose tablets.

4. Quick Disintegrating Tablets

   SMCC possesses a large specific surface area and excellent disintegration properties, making it particularly suitable for formulations requiring rapid disintegration, such as orally disintegrating tablets and traditional Chinese medicine dispersible tablets.

5. Applicable to traditional Chinese medicine or drugs that are sensitive to moisture

   Most traditional Chinese medicines are prone to moisture absorption and agglomeration. Using SMCC as a diluent can effectively prevent stickiness and moisture absorption during the preparation of dispersible tablets from Chinese herbal extracts, while also protecting the product from efficacy loss or caking caused by humidity during long-term storage and transportation.

Model SH-SMCC 50 can be used to improve powder flowability and compressibility, and is also suitable for wet granulation. SH-SMCC 90 offers better flowability than SMCC 50 and is primarily used for direct compression processes. SH-SMCC HD 90 exhibits higher bulk density, superior flowability, and enhanced disintegration performance compared to SMCC 90.