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Company news about Silicified Microcrystalline Cellulose Overview and Applications

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Ms. Haileeping
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Silicified Microcrystalline Cellulose Overview and Applications

2025-07-25

Silicified Microcrystalline Cellulose


Registration No.:F20170000264   DMF:036227


Introduction  


The colloidal silica-coated microcrystalline cellulose composite material is prepared by spray drying after co-processing of 98% microcrystalline cellulose and 2% colloidal silica. It is widely used in solid preparations (such as tablets and capsules).


Advantages  

Improving fluidity: The colloidal silica is uniformly dispersed on the surface of MCC particles, reducing the friction between particles and significantly improving the flowability of the powder, making it suitable for high-speed tabletting processes.

2. Enhancing compressibility: The plastic deformation ability of MCC combined with the filling effect of colloidal silica increases the hardness and anti-breakage property of tablets, reducing the risk of cracking during the tabletting process.

3. Optimizing drug release: With a more uniform pore structure, it can adjust the disintegration time and the rate of drug dissolution, suitable for rapid-release or sustained-release formulations.

4. Reducing excipient usage: The synergistic effect may reduce the total excipient usage (such as reducing the addition of additional flow aids), simplifying the prescription design.

5. Process stability: The co-processing method ensures the uniformity of components, avoids the possible stratification problem in physical mixing, and improves batch-to-batch consistency.


The colloidal silica-coated microcrystalline cellulose composite material combines the principles of materials science and formulation technology to overcome the limitations of traditional excipients in terms of fluidity, compressibility and stability. It has become an efficient excipient choice for the development of modern solid dosage forms. Its advantage lies in its "one-step" multi-functional characteristics, which can significantly enhance production efficiency and product quality.

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Company news about-Silicified Microcrystalline Cellulose Overview and Applications

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Silicified Microcrystalline Cellulose Overview and Applications

2025-07-25

Silicified Microcrystalline Cellulose


Registration No.:F20170000264   DMF:036227


Introduction  


The colloidal silica-coated microcrystalline cellulose composite material is prepared by spray drying after co-processing of 98% microcrystalline cellulose and 2% colloidal silica. It is widely used in solid preparations (such as tablets and capsules).


Advantages  

Improving fluidity: The colloidal silica is uniformly dispersed on the surface of MCC particles, reducing the friction between particles and significantly improving the flowability of the powder, making it suitable for high-speed tabletting processes.

2. Enhancing compressibility: The plastic deformation ability of MCC combined with the filling effect of colloidal silica increases the hardness and anti-breakage property of tablets, reducing the risk of cracking during the tabletting process.

3. Optimizing drug release: With a more uniform pore structure, it can adjust the disintegration time and the rate of drug dissolution, suitable for rapid-release or sustained-release formulations.

4. Reducing excipient usage: The synergistic effect may reduce the total excipient usage (such as reducing the addition of additional flow aids), simplifying the prescription design.

5. Process stability: The co-processing method ensures the uniformity of components, avoids the possible stratification problem in physical mixing, and improves batch-to-batch consistency.


The colloidal silica-coated microcrystalline cellulose composite material combines the principles of materials science and formulation technology to overcome the limitations of traditional excipients in terms of fluidity, compressibility and stability. It has become an efficient excipient choice for the development of modern solid dosage forms. Its advantage lies in its "one-step" multi-functional characteristics, which can significantly enhance production efficiency and product quality.

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